(81) Obesity Should No Longer Be a Contraindication to Pediatric Heart Transplantation
نویسندگان
چکیده
PurposeBody mass index (BMI) is a predictor of mortality in adult heart transplant (HTx) patients. However, the impact BMI pediatric HTx unclear and many programs consider obesity contraindication to transplantation. This study examines effect on patients.MethodsUsing United Network for Organ Sharing database, recipients between ages 2 18 years from 1988-2021 were identified. Patients classified as underweight (BMI <5th percentile), normal weight (5-85th), overweight (86-95th), obese (<95th). Variables associated with survival identified used propensity score matching.ResultsA total 7,487 patients included prior matching, which 58% (4,314/7,487) had BMI, 19% (1,396/7,487) underweight, 11% (851/7,487) overweight, 12% (926/7,487) obese. Median age was 12 (IQR 6 - 15). There differences patient characteristics. Multivariable analysis revealed age, female gender, renal dysfunction, hepatic pre-operative ECMO risk factors poor survival. A diagnosis dilated cardiomyopathy protective. Propensity matching conducted these variables. no free (HR 1.01, 95% CI 0.9 1.2) or 1.17, 1.4) groups (Figure). An 1.23, 1.1 1.4; median 10.6 vs. 13.1, p = 0.0046).ConclusionIn HTx, itself not decreased but often can affect Use threshold (e.g., 35 ≥ 95th percentile) may be prudent should assessed similar manner non-obese Efforts improve pursued hopes improving outcomes. Body Using matching. 0.0046). In
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ژورنال
عنوان ژورنال: Journal of Heart and Lung Transplantation
سال: 2023
ISSN: ['1053-2498', '1557-3117']
DOI: https://doi.org/10.1016/j.healun.2023.02.097